Submitted: 21 Dec 2019
Revision: 16 Mar 2020
Accepted: 20 Mar 2020
ePublished: 21 Jul 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Int J Phytocos Nat Ingred. 2020;7(1): 3.
doi: 10.15171/ijpni.2020.03
  Abstract View: 3251
  PDF Download: 2101

Review Article

Drug interaction of chemotherapy drugs and medicinal plants

Gabriela Quirino Alves, Jenyffer Kyara Chaves Brito, Iran Alves da Silva, Ana Luiza Florencio Galvão de Queiroz, Pedro Rafael de Almeida Melo, Matheus Marques do Nascimento, Cynthia Gisele de Oliveira Coimbra*

Abstract

Introduction: The treatment of cancer is considered to be one of the most challenging problems in medicine. Amongst the most used treatments is the usage of herbal medicines, which helps both in prevention and cure of the disease. Although, the use of medicinal plants for treatment of cancer is harmless or even beneficial to patients but presents potential risk when combined with prescribed drugs. Drug interaction during cancer treatments therefore, is an issue that affects the Brazilian population.Methods: To analyze the drug interactions between chemotherapeutic agents and medicinal plants, a systematic literature review was performed with articles published in English and Portuguese between 2012 and 2019 from the databases such as PubMed and ScienceDirect. Search was carried out with the help of the Boolean Operator (AND) using following keywords: medicinal plants, drug interaction, chemotherapy, and herbal medicine. We found 149 articles in PubMed and 625 articles in ScienceDirect. The selection of articles for this study was done first by excluding repeated articles, then selecting articles by title, then by summary, and the last step was to read the full articles. Finally, twelve articles contributed to the research.Results and Discussion: A systematic research revealed that 5 medicinal plants, such as St. John’s wort (Hypericum perforatum), Ginger (Zingiber officinale), Black cohosh (Cimicifuga racemosa), Celandine (Chelidonium majus) and Mango (Mangifera indica) containing metabolites such as polyphenols, alkaloids, flavonoids, saponins and others interacted with chemotherapeutic agents, such as irinotecan, tamoxifen, docetaxel and paclitaxel. In addition, many medicinal plants are used indiscriminately, without proper medical and pharmaceutical guidance in cancer treatment, to minimize side effects, such as nausea, headache and low immunity, that can cause harm to the patient.
Keywords: Medicinal plants, Chemotherapy, Interaction, Cancer
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 3251

Your browser does not support the canvas element.


PDF Download: 2101

Your browser does not support the canvas element.